Diversifying USAID’s partner base is an important component of locally-led development, because it helps mobilize the increasing number of funders of all types engaged in the development efforts of partner countries around the world. Promising prospective local, U.S., and international organizations that are NUPs represent untapped potential for partnership and impact, and funding more of them requires new initiatives and targeted approaches, such as NPI EXPAND. Some potential partners with good ideas and innovative approaches have—or believe they have—limited capacity or opportunity to compete for direct U.S. funding because of compliance and solicitation requirements and/or the dollar amount and scope of awards. NPI EXPAND supports USAID’s shift in focus to increasing and sustaining relationships with such NUPs, especially those locally established and in the private sector. Every effective, more sustainable NUP contributing to the health sector with skilled staff, strong internal systems, and productive networks promotes utilization of high-priority services and improved health outcomes.